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Wednesday, May 20, 2020 | History

2 edition of Modulation of HIV-1 Rev function by SR and SR-related proteins. found in the catalog.

Modulation of HIV-1 Rev function by SR and SR-related proteins.

Jodi Lynne Bubenik

Modulation of HIV-1 Rev function by SR and SR-related proteins.

by Jodi Lynne Bubenik

  • 261 Want to read
  • 29 Currently reading

Published .
Written in English


About the Edition

Due to their parasitic nature, viruses are required to use existing cellular processes to replicate. This permits viruses to be used as model systems in which to study cellular pathways. HIV-1 is a valuable viral system in which to study RNA metabolism, as expression of the entire complement of HIV-1 viral proteins depends on the competing activities of viral RNA splicing and export. The virus must also transport incompletely processed RNAs that would normally be retained in the nucleus. For this activity, the virus encodes a nucleocytoplasmic shuttling protein called Rev. Rev is crucial to the lifecycle of the virus, as in the absence of Rev function, the HIV-1 proteins required for replication cannot be produced. While its role within the virus is well-understood, the impact of the cellular environment on Rev function has not been explored. This study identifies members of the SR and SR-related protein families as cellular factors that influence Rev function. These proteins are capable of both positively and negatively affecting Rev function. This suggests that the relative levels of SR proteins may render a cell permissive or non-permissive for Rev function. Cellular environments that are not conducive to Rev function will be less likely to support active infections and may drive the virus into a latent state. Thus, investigating the influence of cellular proteins on Rev function may lead to an increased understanding of latent versus productive infections. This information could prove valuable for any future design of antiviral therapies directed against Rev.

The Physical Object
Pagination190 leavees.
Number of Pages190
ID Numbers
Open LibraryOL19475635M
ISBN 100494028297


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Modulation of HIV-1 Rev function by SR and SR-related proteins by Jodi Lynne Bubenik Download PDF EPUB FB2

Although several SR proteins have been implicated in RNA export and translation of select mRNAs (Huang et al.,Sanford et al., ) and the modulation of HIV-1 RNA expression in the context of mouse cell lines (Swanson et al., ), for the purposes of this review, focus will be on their role in the control of HIV-1 RNA splicing (see Author: Ahalya Balachandran, Liang Ming, Alan Cochrane.

Role of viral regulatory and accessory proteins in HIV-1 replication Article Literature Review (PDF Available) in Frontiers in Bioscience October with 1, Reads. SR proteins play pivotal roles in neuronal function.

Alternative splicing occurs with a high frequency in Fig. 9 Absence of Pnn, SR proteins and SC35 in astrocytes. Two major groups of proteins, hnRNPs (green) and SR or SR related proteins (red), bind to splicing regulator elements; the protein:RNA interaction is indicated by shading.

The protein complex assembling around the exon stabilizes binding of spliceosomal components, indicated in by: 7. ZhongXY, WangP, HanJ, RosenfeldMG, FuXD () SR proteins in vertical integration of gene expression from transcription to RNA processing to translation.

Mol Cell 1– 8. WangGS, CooperTA () Splicing in disease: disruption of the splicing code and the decoding machinery. Nat Rev. Gene Therapy and Molecular Biology Vol 5, page 3. Figure 2: Promoter strength comparison by IL-2 production.

MCF-7 cells were plated overnight at a density of x cells per well in a six well. The number of factors known to participate in the DNA damage response (DDR) has expanded considerably in recent years to include splicing and alternative splicing factors.

While the binding of splicing proteins and ribonucleoprotein complexes to nascent transcripts prevents genomic instability by deterring the formation of RNA/DNA duplexes, splicing factors are also recruited to, or removed.

This banner text can have markup. web; books; video; audio; software; images; Toggle navigation. Full text of "USPTO Patents Application " See other formats. The PcG proteins function in two distinct Polycomb Repressive Complexes, PRC1 and PRC2.

Genome-wide binding site analyses have been carried out for PRC1 and PRC2 in mouse ESCs and for PRC2 in human ESCs (Lee T. I., et al., Control of developmental regulators by Polycomb in human embryonic stem cells. Introduction of double stranded RNA into cells, cell culture, organs and tissues, and whole organisms, particularly vertebrates, specifically attenuates gene expression.

AR-v7 protein expression is regulated by protein kinase and phosphatase. PubMed Central. Li, Yinan; Xie, Ning; Gleave, Martin E.; Rennie, Paul S.; Dong, Xuesen.

Atf6 plays protective and pathologic roles in fatty liver disease due to endoplasmic reticulum stress. PubMed Central. Cinaroglu, Ayca; Gao, Chuan; Imrie, Dru; Sadler, Kirsten C. A host of other proteins such as RNA helicases and SR proteins assist in dynamic assembly of the complex and in enhancing intron recognition (reviewed in Brow, ; Jurica and Moore, ).

Catalysis of the splicing reaction takes place by the ordered assembly of the various snRNPs on the pre-mRNA and the formation of several intermediate. alt spilicing 3 - Free download as PDF File .pdf), Text File .txt) or read online for free.

Patent application title: REPROGRAMMING COMPOSITIONS AND METHODS OF USING THE SAME Inventors: John D. Mendlein (Leucadia, CA, US) Francine S. Farouz (La Jolla, CA, US) R.

Scott Thies (San Diego, CA, US). The strongest download Knowledge and Innovation in Regional Industry: An Entrepreneurial Coalition (Studies in Global of this download bans the new-style xenotransplant of Archived Historical patients it uses.

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mol bio. The present invention provides compositions and methods of using the compositions to alter the developmental potency of a cell. The present invention provides in vivo and ex vivo cell reprogramming and programming methods suitable for autologous cell therapy and regenerative medicine.

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